Cytokines Series: Brain Derived Neurotrophic Factor -BDNF

In the brain, BDNF is expressed predominantly in the hippocampus, cortex, and synapses of the basal forebrain areas where it is vital to learning, memory, and higher thinking. BDNF is also expressed in muscles. BDNF selectively supports the survival of primary sensory neurons, retinal ganglia and the survival and differentiation of certain cholinergic and dopaminergic neurons. It also modulates neural plasticity and predisposition to behaviors. BDNF can recover re-innervation in the mature cerebellum thus it is applicable in trauma of the central nervous system (CNS). Both BDNF and NGF express neuroprotective effects on myelin, thus they are indicated in multiple sclerosis (MS). Exposure to stress and the stress hormone corticosterone has been shown to decrease the expression of BDNF which can lead to depression. On the other hand, the expression of BDNF is increased by voluntary exercise, caloric restriction, intellectual stimulation, curcumin, the neurotransmitter glutamate and various antidepressants drugs.BDNF is also a critical regulator of drug dependency since it causes cravings in opiate-dependent people; on the other hand BDNF has a role in maintaining long-term abstinence from alcohol in people with alcohol dependency.

More information about this and other health topics can be found in my books “Low Dose Medicine” and “Cure Without Side effects” by following these links: ►►►https://amzn.to/3Bbx8fd ►►►https://amzn.to/36iaqDU

Cytokines Series: Nerve Growth Factor – NGF

This video introduces the cytokine Nerve Growth Factor – NGF, an important nerve regenerative and repairing neurotrophine. NGF is synthesized in the hypothalamus, pituitary, thyroid gland, testis, and it is also produced by vascular smooth muscle cells and fibroblasts. The expression of NGF in specific neurons of the central nervous system (cortex, hippocampus) can be influenced positively by glutamate and negatively by GABA stimulating neuronal activity. NGF stimulates the growth and differentiation of B-cells and the growth of T-cells and also promotes the proliferation of mast cells. Vitamin D3 is potent inducer of NGF synthesis (a possible reason for vitamin D antidepressant action), while glucocorticoids are potent NGF inhibitors.

More information about this and other health topics can be found in my books “Low Dose Medicine” and “Cure Without Side effects” by following these links: ►►►https://amzn.to/3Bbx8fd ►►►https://amzn.to/36iaqDU

To check the Low dose Medicine health kit follow this link: ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine

DISCLAIMER: Nothing contained in this video is intended nor can be taken to diagnose, treat, or cure any disease. It is for informational purposes only.

Cytokines Series: Insulin Like Growth Factor 1 – IGF 1

This is the thirteenth of a series of short videos on Low dose Medicine and in particular Cytokines. This video introduces the cytokine IGF 1 , the ‘anti age’ growth factor. Insulin-like growth factor 1 (IGF-1), is a protein similar in molecular structure to insulin mainly produced by the liver. Its production is stimulated by the growth hormone (GH) and can be retarded by under nutrition or malnutrition, growth hormone insensitivity, lack of growth hormone receptors and it is also reduced with age. In children, it stimulates bone growth and development of organs such as the heart, liver, and kidneys. In humans, the growth hormone (GH) made in the anterior pituitary gland stimulates the liver to produce insulin-like growth factor 1 (IGF-1) which then stimulates and has a growth-promoting effect on almost every cell in the body, especially kidney, muscles, cartilage, liver, nerves, skin, hematopoietic cells, and lungs.

More information about this and other health topics can be found in my books “Low Dose Medicine” and “Cure Without Side effects” by following these links: ►►►https://amzn.to/3Bbx8fd ►►►https://amzn.to/36iaqDU

To check the Low dose Medicine health kit follow this link: ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine

DISCLAIMER: Nothing contained in this video is intended nor can be taken to diagnose, treat, or cure any disease. It is for informational purposes only.

Cytokines Series: Tumor Necrosis Factor – TNF α

This is the fourteenth of a series of short videos on Low Dose Medicine and in particular Cytokines. This video introduces the cytokine Tumor Necrosis Factor α , an important inflammatory cytokine. TNF-alpha has a wide spectrum of biological activities, generally together with IL-1 and IL-6, such as prostaglandin synthesis by hypothalamic cells, HPA (hypothalamic-pituitary-adrenal) axis stimulation by stimulating the release of corticotropin releasing hormone (CRH), appetite suppression, fever induction, hepatocytes stimulation for the production of acute phase proteins, hypoglycemia, insulin resistance and stimulation of phagocytosis on macrophages. High concentrations of TNF induce shock-like symptoms whereas the prolonged exposure to low concentrations of TNF can result in cachexia.

More information about this and other health topics can be found in my books “Low Dose Medicine” and “Cure Without Side effects” by following these links: ►►►https://amzn.to/3Bbx8fd ►►►https://amzn.to/36iaqDU

To check the Low dose Medicine health kit follow this link: ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine

DISCLAIMER: Nothing contained in this video is intended nor can be taken to diagnose, treat, or cure any disease. It is for informational purposes only.